Retrograde brain perfusion beyond the venous valves

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Unclamping the inferior vena cava during retrograde cerebral perfusion increases the safe range of retrograde perfusion pressures and improves brain perfusion.

We investigated the effect of different methods of management of the inferior vena cava (IVC) during retrograde cerebral perfusion (RCP) on the relationships between RCP pressure, regional cerebral blood flow, tissue oxygenation, and intracranial pressure (ICP). Fourteen pigs were subjected to hypothermic (15 degrees C) RCP at RCP pressures varying from 10 to 110 mmHg with clamping (closed grou...

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Using quantitative double-tracer autoradiography, we examined the tolerance of the rat cerebral venous system in focal cerebral ischemia to retrograde perfusion pressure into the inferior cerebral vein. At perfusion pressures of less than 150 mm Hg, there was no significant change in local cerebral blood flow (LCBF) and blood-brain barrier (BBB) permeability. At pressures of greater than 170 mm...

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The effect of aging on venous valves.

OBJECTIVE Age is the strongest risk factor for venous thrombosis. Vessel wall changes such as thickening of venous valves may be one of the contributing mechanisms. We determined thickness and function of venous valves in the popliteal vein with ultrasound in 77 healthy individuals. METHODS AND RESULTS The study included 6 age groups ranging from 20 to 80 years old. Thickness of the valves wa...

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ژورنال

عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery

سال: 1996

ISSN: 0022-5223

DOI: 10.1016/s0022-5223(96)70399-9